The fibrinolytic activity of streptokinase activated human plasmin.
نویسنده
چکیده
منابع مشابه
Mechanisms involved in enhancement of plasma fibrinolytic activity by chloroform.
The effects of a single 1-min extraction with chloroform (CHCl3) on plasma fibrinolytic activity has been examined by 125I-fibrin solid phase assay, using normal plasma and plasma depleted of plasminogen (PLG) by lysine-Sepharose affinity chromatography. Fibrinolytic activity of normal plasma is increased (40%-175%), and more than 95% of antiplasmin activity is removed. The increase is demonstr...
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Plasminogen, a normal constituent of human blood plasma, can be activated in various ways to yield the proteolytic enzyme plasmin capable of dissolving fibrin clots and of hydrolyzing a variety of other proteins and synthetic amino acid esters. The activation by the bacterial product streptokinase has been widely studied in the past and appears to proceed through a two-stage reaction: the inter...
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Although there is little doubt that more than one proteolytic enzyme occurs in plasma, plasmin (fibrinolysin) is the only such enzyme which has been definitely identified. Astrup and Permin,12 on the basis of differences in susceptibility to activation by streptokinase and fibrinokinase, have suggested that there are two precursors of fibrinolytic enzymes in human blood. They have designated th...
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Tillett and Garner (1) discovered that an extracellular protein elaborated by certain strains of streptococci produces the lysis of clots which contain human fibrinogen or thrombin. M&tone demonstrated that the bacterial product was not in itself fibrinolytic but interacted with a lytic material in human plasma (2). The situation was greatly clarified and a rational nomenclature introduced by C...
متن کاملImmunohistochemical Study of Thrombolytic Mechanisms.
I N PREVIOUS REPORTS1-3 various methods, including radiotracer studies, revealed the capacity of plasmin to adsorb selectively to preformed venous and arterial clots. Components of the fibrinolysin system were labeled with iodine131 and their distribution studied following intravenous administration. The highest degree of adsorption to fibrin clots was exhibited by human plasminogen activated w...
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ورودعنوان ژورنال:
- The Journal of clinical investigation
دوره 33 7 شماره
صفحات -
تاریخ انتشار 1954